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. 2015 Jul 1;29(10):4285–4298. doi: 10.1096/fj.15-272526

Figure 6.

Figure 6.

Amphetamine-induced hyperthermia is attenuated in TRPV1 KO mice. A) Core body temperature recording following d-amphetamine (10 mg/kg, s.c.; n = 7) or vehicle (saline, 5 ml/kg, s.c.; n = 5) administration to TRPV1 WT and KO mice. B) The hyperthermic index was analyzed as area under the temperature curve during the 120 to 290 min period for vehicle and d-amphetamine-treated mice. C) Activity levels following d-amphetamine (10 mg/kg, s.c.; n = 7) or vehicle (saline, 5 ml/kg, s.c.; n = 5) administration to TRPV1 WT and KO mice. D) Respective activity index analyzed as area under the activity curve during the 120 to 290 min period. Results are means ± sem. *P < 0.05, **P < 0.01, and ***P < 0.001 vs. control; ###P < 0.001 vs. genotype using 2-tailed Student’s t test and 2-way ANOVA and Bonferroni’s post hoc test.