Table 5.
Locations of significantly greater activation for the G-carriers of the OPRM1 gene as compared to the A-allele homozygotes (AG/GG vs. AA) for the pre- versus post-priming scan contrast of alcohol- versus water-cues, controlling for alcoholism severity (whole-brain cluster-corrected at Z>2.3, p<0.05). No results were obtained for the reverse contrast (AA vs. AG/GG).
| Pre- vs. Post-Priming: AG/GG vs. AA
| ||||||
|---|---|---|---|---|---|---|
| Brain Region | Hemisphere | Cluster Voxels | Max Z | X | Y | Z |
|
| ||||||
| Parietal Operculum Cortex/Planum Temporale | L | 349 | 3.45 | −54 | −38 | 20 |
| - Posterior Supramarginal Gyrus | L | 3.26 | −54 | −44 | 28 | |
| Anterior Supramarginal Gyrus | R | 333 | 3.09 | 64 | −30 | 30 |
| - Parietal Operculum Cortex | R | 3.05 | 48 | −26 | 18 | |
| - Central Opercular Cortex | R | 2.61 | 54 | −18 | 20 | |
| White Matter/Caudate | L | 306 | 3.21 | −28 | −8 | 30 |
| - Thalamus | L | 2.88 | −14 | −14 | 14 | |
| - Putamen | L | 2.86 | −24 | 4 | 14 | |