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Infectivity of YU2 (clade B) and ZM135M.PL10a (clade C) glycan-deletion pseudoviruses. A panel of glycan-deletion mutant viruses was created in either YU2 (A) or ZM135M.PL10a (B) gp160. Pseudovirus stocks were generated by transfection of 293T cells, and tested for infectivity in a TZM.bl cell-based assay. TZM.bl cells were infected with serial dilutions of each glycan mutant or parental wild-type (WT) virus, and TCID50/ml was calculated.
