FIG. 1.

Correlations between change from baseline to postdose 1 in pH1N1-specific CD4⁺MIP1β⁺% and regulatory T cell subsets. Data were derived from peripheral blood mononuclear cells (PBMC) of 52 HIV-infected pregnant women collected before and 21–28 days after the administration of a double-dose of pH1N1 IIV1. Data points represent pH1N1-specific T cell subset frequencies at postvaccination after subtraction of prevaccination frequencies. The coefficients of correlations and p values measured with the Spearman correlation test shown on the graphs demonstrate highly significant associations between the changes in CD4⁺MIP1β⁺% (x axes), representing Th1 responses, in response to vaccination and selected Treg- and Breg-subset% changes (y axes) after vaccination.