Figure 3.
(A–D) Representative images of whole liver lobes from mice (C57BL/6) injected with QuadYF-TV packaging either a ubiquitously expressing chicken β-actin (CBA) promoter (A and B) or vascular endothelial cell-specific (VECad) promoter (C and D), showing gross histological features; note the relative absence of hepatocyte transduction when using the endothelial cell-specific promoter. (E–H) Representative images of whole lung lobes harvested from unmodified rAAV2- and QuadYF-TV-injected mice (C57BL/6), showing gross histological features; note the relative absence of lung transduction in rAAV2-injected animals. Red signal (A–H), anti-GFP immunostaining. Scale bars, 100 μm.