Table 2.
SPECT Pharmacokinetic–Distance Parameters by Product; Median (Interquartile Range)
| Radiolabeled analyte±sRAI | Hours | Aqueous fluid | Aqueous gel | Lipid fluid | Lipid gel |
|---|---|---|---|---|---|
| Dmax (cm) | |||||
| DTPA−sRAI | 2 h | 23.2 (20.7, 28.8) | 21.1 (19.0, 25.3) | 19.8 (0.0, 24.9)* | 19.8 (15.3, 24.6) |
| 4 h | 23.0 (14.9, 25.1) | 12.9 (11.6, 20.0) | 17.3 (6.0, 24.1)* | 21.3 (3.8, 24.9) | |
| DTPA+sRAI | 2 h | 20.0 (17.1, 21.6) | 19.9 (17.9, 21.5) | 18.9 (13.6, 24.6)* | 18.5 (15.3, 21.9)* |
| 4 h | 18.3 (16.9, 22.6) | 20.6 (18.5, 22.6) | 14.3 (12.3, 16.0)* | 16.1 (13.3, 17.8)* | |
| Sulfur colloid+sRAI | 2 h | 23.5 (22.1, 28.7) | 21.2 (19, 29.3) | 25.4 (22.5, 31.6) | 25.6 (19.6, 27.3) |
| 4 h | 19.9 (15.7, 26.4) | 22.3 (17.2, 23.6) | 20.0 (13.0, 22.6) | 23.1 (11.9, 25.2) | |
| DCmax (cm) | |||||
| DTPA−sRAI | 2 h | 5.8 (3.6, 9.9) | 7.2 (5.4, 12.1) | 7.0 (0.0, 12.4) | 8.5 (5.8, 11.1) |
| 4 h | 5.3 (3.3, 7.2) | 5.1 (2.0, 8.3) | 7.3 (2.4, 12.2) | 8.7 (0.8, 10.5) | |
| DTPA+sRAI | 2 h | 7.2 (5.2, 10.2) | 6.1 (4.4, 10.0) | 6.8 (5.0, 12.0) | 9.1 (6.6, 11.8) |
| 4 h | 5.6 (4.2, 6.2) | 5.2 (3.9, 8.6) | 5.7 (3.6, 8.9) | 6.1 (4.6, 7.8) | |
| Sulfur colloid+sRAI | 2 h | 10.3 (4.9, 12.7) | 9.4 (4.5, 11.8) | 12.7 (8.5, 17.1)* | 10.1 (7.6, 12.6) |
| 4 h | 8.0 (5.5, 9.3) | 7.5 (5.1, 10.4) | 12.5 (6.2, 13.7)* | 8.9 (5.0, 11.3) | |
| Dave (cm) | |||||
| DTPA−sRAI | 2 h | 8.5 (5.3, 11.6) | 7.2 (6.3, 9.6) | 7.8 (0, 11.4) | 8.3 (6.1, 12.0) |
| 4 h | 6.8 (4.7, 10.2) | 6.3 (4.7, 7.5) | 9 (2.4, 12.1) | 8.9 (1.0, 12.1) | |
| DTPA+sRAI | 2 h | 8.8 (8.1, 9.2) | 7.9 (6.8, 10.5) | 6.7 (6.2, 13.3) | 8.4 (7.3, 10.4) |
| 4 h | 8.0 (6.6, 9.5) | 8.8 (7.5, 10.2) | 6.8 (5.1, 8.7) | 6.1 (5.6, 7.5) | |
| Sulfur colloid+sRAI | 2 h | 10.0 (7.5, 12.5) | 8.4 (6.6, 11.2) | 11.0 (9.3, 14.9) | 10.5 (7.1, 13.9) |
| 4 h | 8.6 (6.3, 9.9) | 8.6 (7.9, 10.5) | 9.5 (8.2, 10.5) | 9.7 (5.4, 11.3) | |
| Dmin (cm) | |||||
| DTPA−sRAI | 2 h | −3.9 (−5.8, −2.2) | −3.6 (−5.0, −1.2) | −3.4 (−5.1, −1.7) | −3.4 (−4.3, −1.2) |
| 4 h | −3.8 (−3.7, −3.4) | −2.5 (−3.4, 0.8) | −3.1 (−4.4, −1.0) | −3.4 (−4.8, −2.0) | |
| DTPA+sRAI | 2 h | −1.4 (−2.4, 0.1) | −1 (−1.7, 0.1) | −1.0 (−2.4, 0.3) | −1.3 (−2.2, 0.0) |
| 4 h | −0.6 (−1.5, 0.1) | −0.8 (−2.7, 0.0) | −0.3 (−2.4, 0.0) | −1.2 (−2.0, −0.3) | |
*
p<0.05, multilevel analysis compared to aqueous fluid after adjusting by time from dose administration.
Note: 99mTc-sulfur colloid in plasma was below detection limits and not listed.
sRAI, simulated receptive anal intercourse with semen surrogate including radiolabeled HIV surrogate 99mTc-sulfur colloid in autologous seminal plasma; DTPA, diethylene triamine pentaacetic acid.