Table 1. Comparison of the inhibitory activity of the compounds on wild-type and mutated FABP4.
Compound | Inhibition at 20 μmol/La (%) |
Inhibition at 50 μmol/La (%) |
||||||
---|---|---|---|---|---|---|---|---|
Wild type | S55A | D76A | R126A | Wild type | S55A | D76A | R126A | |
Lab | 69.7±0.6 | 72.8±0.7 | 63.8±0.6 | 36.7±4.0 | 86.0±0.5 | 92.9±0.7 | 75.3±2.2 | 46.5±4.4 |
BBR | 66.9±0.6 | 48.5±1.0 | 46.2±0.6 | 52.5±3.5 | 84.2±0.5 | 67.7±2.0 | 56.8±2.0 | 58.6±2.3 |
a Values are means of triplicate experiments with standard deviation values.
b LA: linoleic acid.