Figure 3.

Biological processes proposed to induce changes in oedema apparent diffusion coefficient (ADC) values during acute stage of intracerebral haemorrhage. The pathophysiological process within perihaematomal oedema is complicated and relates to both systemic and local responses. This will induce various changes in the ADC values. Even a single biological response, such as thrombin formation, will lead to different kinds of ADC changes. Therefore, the diffusion signal of oedema at different areas with increasing or decreasing changes would be obscured in the overall mean ADC but easily discriminated by a functional diffusion map. B.B.B., blood–brain barrier; ICP, intracranial pressure; RBC, red blood cell.