TABLE 3.
Colonization of murine tissues following challenge with S. Typhimuriuma
| No. of days postinoculation with NC1040 | NC1040 CFU/g (no. of culture-positive mice/total no. of mice) |
||
|---|---|---|---|
| Intestine | Liver | Spleen | |
| 1 | 5.7 ± 1.3 (4/4) | 2.8 (1/4) | 2.7 ± 0.6 (2/4) |
| 3b | 5.0 ± 1.2 (3/3) | 3.8 ± 1.3 (3/3) | 4.3 ± 1.0 (3/3) |
| 4b | 5.1 ± 1.7 (3/3) | 4.4 ± 1.4 (3/3) | 4.4 ± 1.3 (3/3) |
| 8 | 5.5 ± 1.5 (4/4) | 4.4 ± 1.4 (4/4) | 5.1 ± 0.6 (4/4) |
a
C3H/HeN female mice (4 to 6 weeks old) were inoculated with ∼5 × 108 CFU of the kanamycin-resistant (fnr′::ha) “wild-type” strain (NC1040). Data shown are the mean log10 CFU values per gram of intestinal content or tissue homogenate from the indicated number of culture-positive mice among those sampled (shown in parentheses), with a detection limit of <2.3 log10 CFU/g.
b
A mouse in this group was found dead on the day of sampling.