TABLE 4.
Colonization of murine tissues following challenge with S. Enteritidisa
| No. of days postinoculation with BTNC0025 | BTNC0025 CFU/g (no. of culture-positive mice/total no. of mice) |
||
|---|---|---|---|
| Intestine | Liver | Spleen | |
| 1 | 5.3 ± 1.1 (4/4) | 2.4 ± 0.1 (3/4) | 2.5 ± 0.3 (2/4) |
| 3 | 3.6 ± 0.8 (4/4) | 5.2 ± 1.5 (4/4) | 5.5 ± 1.5 (4/4) |
| 6 | 4.1 ± 0.9 (4/4) | 5.6 ± 1.1 (4/4) | 6.9 ± 1.0 (4/4) |
| 8b | 5.1 (1/1) | 4.9 (1/1) | 5.9 (1/1) |
a
C3H/HeN female mice (4 to 6 weeks old) were inoculated with ∼5 × 108 CFU of the rifampin-resistant “wild-type” strain (BTNC0025). Data shown are the mean log10 CFU values per gram of intestinal content or tissue homogenate from the indicated number of culture-positive mice among those sampled (shown in parentheses), with a detection limit of <2.3 log10 CFU/g.
b
Three mice in this group were found dead on the day of sampling.