Table 3.
Observed effect of BMI on recurrence-free survival: results of multivariable proportional hazards model (n = 1845, 32% events)
| Variable | HR comparison | HR (95% CI) | P* |
|---|---|---|---|
| BMI | 5-unit increase | 1.08 (1.02 to 1.14) | .01 |
| No. nodes† | 1: 10 | 0.44 (0.37 to 0.52) | <.001 |
| Tumor size† | 2 cm: 5 cm | 0.72 (0.62 to 0.82) | <.001 |
| Menopause | Post: pre | 1.11 (0.94 to 1.31) | .22 |
| ER status | Negative: positive | 1.54 (1.31 to 1.82) | <.001 |
| Sequence | Sequential: concurrent | 1.05 (0.89 to 1.23) | .57 |
| Dose density | q 3 wks: q 2 wks | 1.21 (1.03 to 1.43) | .02 |
* P values are from a Wald-type test in the multivariable proportional hazards model. BMI = body mass index; CI = confidence interval; ER = estrogen receptor; HR = hazard ratio.
† A square root transformation was used in analyses as performed in Citron et al. (2003).