Table 3. Multivariable logistic regression modelsa reporting ORs and 95% CIs for reporting mental health dysfunction within the five questionsb comprising the mental health scale of the SF-36 survey, by specific potential demographic, cancer, social, and economic factors.

	Have you been a very nervous person? (question 9b)			Have you felt so down in the dumps that nothing could cheer you up? (question 9c)			Have you felt calm and peaceful? (question 9d)			Have you felt downhearted and blue? (question 9f)			Have you been a happy person? (question 9h)
Characteristic	OR (95% CI)	P-value	Pheterogeneityc (Ptrendd)	OR (95% CI)	P-value	Pheterogeneityc (Ptrendd)	OR (95% CI)	P-value	Pheterogeneityc (Ptrendd)	OR (95% CI)	P-value	Pheterogeneityc (Ptrendd)	OR (95% CI)	P-value	Pheterogeneityc (Ptrendd)
Sex
Male	1.0			1.0			1.0			1.0			1.0
Female	1.4 (1.3–1.6)	<0.001	<0.0001	1.7 (1.5–1.9)	<0.001	<0.0001	1.6 (1.5–1.8)	<0.001	<0.0001	1.6 (1.4–1.7)	<0.001	<0.0001	1.2 (1.1–1.4)	<0.001	<0.0001
Diagnosis
Leukaemia	1.0			1.0			1.0			1.0			1.0
Hodgkin lymphoma	1.1 (0.9–1.3)	0.433		1.0 (0.8–1.2)	0.732		1.1 (0.9–1.3)	0.468		1.0 (0.8–1.2)	0.617		1.3 (1.0–1.6)	0.021
Non-Hodgkin lymphoma	1.0 (0.8–1.2)	0.863		1.1 (0.8–1.4)	0.620		1.2 (1.0–1.5)	0.086		0.9 (0.8–1.2)	0.615		1.4 (1.1–1.8)	0.003
Central nervous system	1.3 (1.1–1.5)	0.001		1.2 (1.0–1.4)	0.036		1.2 (1.0–1.3)	0.024		1.1 (1.0–1.3)	0.080		1.4 (1.2–1.6)	<0.001
Neuroblastoma	0.8 (0.6–1.1)	0.116		1.2 (0.9–1.6)	0.124		1.1 (0.9–1.3)	0.535		1.1 (0.9–1.4)	0.432		1.3 (1.0–1.7)	0.041
Non-heritable retinoblastoma	1.1 (0.8–1.3)	0.884		1.0 (0.8–1.4)	0.737		1.1 (0.9–1.4)	0.373		1.1 (0.8–1.3)	0.681		1.4 (1.0–1.8)	0.024
Heritable retinoblastoma	0.8 (0.6–1.1)	0.242		1.1 (0.8–1.5)	0.518		0.8 (0.6–1.1)	0.242		0.9 (0.7–1.2)	0.612		1.2 (0.9–1.6)	0.311
Wilms	0.9 (0.8–1.1)	0.249		0.9 (0.8–1.2)	0.586		1.0 (0.9–1.2)	0.896		0.8 (0.7–1.0)	0.065		1.0 (0.8–1.2)	0.989
Bone sarcoma	1.0 (0.8–1.3)	0.881		1.2 (0.9–1.6)	0.229		1.2 (1.0–1.6)	0.071		1.0 (0.8–1.3)	0.737		1.5 (1.1–1.9)	0.005
Soft tissue sarcoma	0.9 (0.7–1.1)	0.398		1.0 (0.8–1.2)	0.853		1.1 (0.9–1.3)	0.491		1.0 (0.8–1.2)	0.877		1.2 (1.0–1.5)	0.085
Other	0.9 (0.7–1.1)	0.174	0.0022	0.9 (0.8–1.1)	0.481	0.2762	0.9 (0.8–1.1)	0.379	0.1254	0.8 (0.7–1.0)	0.015	0.0273	1.0 (0.8–1.2)	0.898	0.0004
Age at diagnosis
0–4 years	1.0			1.0			1.0			1.0			1.0
5–9 years	1.1 (0.9–1.2)	0.412		1.0 (0.9–1.2)	0.527		1.0 (0.9–1.2)	0.423		1.1 (1.0–1.2)	0.200		1.0 (0.9–1.2)	0.618
10–14 years	1.0 (0.9–1.2)	0.708	0.7132 (0.7301)	1.1 (0.9–1.3)	0.334	0.6190 (0.3569)	1.1 (1.0–1.3)	0.094	0.2444 (0.1029)	1.1 (1.0–1.3)	0.098	0.2266 (0.1072)	1.1 (1.0–1.3)	0.132	0.2990 (0.1519)
Age at questionnaire completion
16–24 years	1.0			1.0			1.0			1.0			1.0
25–34 years	1.1 (1.0–1.3)	0.131		1.2 (1.0–1.4)	0.210		1.2 (1.0–1.3)	0.010		1.3 (1.1–1.5)	<0.001		1.3 (1.1–1.5)	0.001
35–44 years	1.0 (0.9–1.2)	0.852		1.2 (1.0–1.4)	0.103		1.3 (1.1–1.5)	0.002		1.3 (1.1–1.6)	0.001		1.5 (1.3–1.9)	<0.001
45+ years	1.0 (0.8–1.2)	0.666	0.2051 (0.8380)	0.8 (0.6–1.0)	0.050	0.0001 (0.7357)	1.0 (0.8–1.3)	0.731	0.0021 (0.0415)	1.2 (1.0–1.5)	0.078	0.0013 (0.0015)	1.6 (1.2–2.0)	<0.001	<0.0001 (<0.0001)
Marital status
Single	1.0			1.0			1.0			1.0			1.0
Cohabiting	0.8 (0.7–1.0)	0.018		1.0 (0.8–1.2)	0.700		1.1 (1.0–1.3)	0.159		1.0 (0.8–1.2)	0.879		1.1 (0.9–1.3)	0.519
Married	0.7 (0.6–0.8)	<0.001		0.6 (0.5–0.7)	<0.001		0.9 (0.8–1.0)	0.091		0.7 (0.6–0.8)	<0.001		0.7 (0.6–0.8)	<0.001
Separated	1.2 (0.8–1.7)	0.305		1.3 (0.9–1.9)	0.149		1.3 (0.9–1.9)	0.098		1.7 (1.2–2.4)	0.003		1.3 (0.9–1.9)	0.175
Divorced	1.0 (0.8–1.3)	0.916		1.1 (0.8–1.4)	0.588		1.0 (0.8–1.3)	0.822		1.0 (0.8–1.2)	0.872		1.1 (0.9–1.4)	0.469
Widowed	0.9 (0.4–2.1)	0.810	<0.0001	2.1 (0.9–4.6)	0.074	<0.0001	1.3 (0.6–2.9)	0.455	0.0306	1.1 (0.5–2.3)	0.893	<0.0001	1.1 (0.5–2.5)	0.852	<0.0001
Educational attainment
No qualifications	1.0			1.0			1.0			1.0			1.0
Other qualifications	1.0 (0.9–1.2)	0.719		0.9 (0.7–1.0)	0.123		0.9 (0.7–1.0)	0.054		0.9 (0.8–1.1)	0.230		0.9 (0.7–1.1)	0.218
O-levele	0.8 (0.7–0.9)	0.001		0.7 (0.6–0.8)	<0.001		0.8 (0.7–0.9)	0.004		0.8 (0.7–1.0)	0.013		0.8 (0.7–0.9)	0.010
A-levelf	0.7 (0.6–0.9)	<0.001		0.6 (0.5–0.8)	<0.001		0.8 (0.7–0.9)	0.004		0.7 (0.6–0.9)	<0.001		0.8 (0.6–0.9)	0.005
Teaching qualification	0.8 (0.6–1.0)	0.029		0.6 (0.5–0.8)	<0.001		0.8 (0.7–1.0)	0.031		0.8 (0.6–0.9)	0.006		0.7 (0.6–0.9)	0.009
Degree	0.6 (0.5–0.8)	<0.001	<0.0001	0.5 (0.4–0.6)	<0.001	<0.0001	0.8 (0.7–1.0)	0.047	0.0646	0.7 (0.6–0.8)	<0.001	<0.0001	0.7 (0.6–0.9)	0.002	0.0007
SEC
Student	1.0			1.0			1.0			1.0			1.0
Never worked/unemployed	1.3 (1.1–1.6)	0.008		2.6 (2.1–3.2)	<0.001		1.3 (1.1–1.6)	0.006		1.5 (1.2–1.8)	<0.001		1.8 (1.5–2.3)	<0.001
Routine/manual	1.0 (0.9–1.2)	0.892		1.4 (1.2–1.7)	<0.001		1.1 (0.9–1.2)	0.417		1.3 (1.1–1.5)	0.004		1.2 (1.0–1.4)	0.091
Intermediate	0.9 (0.7–1.0)	0.153		1.1 (0.9–1.4)	0.245		1.0 (0.9–1.2)	0.986		1.1 (0.9–1.3)	0.195		1.1 (0.9–1.3)	0.430
Managerial/professional	0.8 (0.6–0.9)	0.009	<0.0001	1.0 (0.8–1.3)	0.766	<0.0001	1.0 (0.8–1.2)	0.816	0.0339	0.9 (0.8–1.1)	0.527	<0.0001	1.0 (0.8–1.2)	0.973	<0.0001

Abbreviations: CI=confidence interval; CNS=central nervous system; NHL=non-Hodgkin lymphoma; OR=odds ratio; SEC=socio-economic classification.

^aAdjusted for age at diagnosis, diagnosis, sex, age at questionnaire completion, marital status, educational attainment, and SEC.

^bTo view full questions, please refer to Figure 1.

^cThe Pheterogeneity (two-sided) is from the likelihood ratio test for heterogeneity in the probability of reporting mental health dysfunction within this specific question, across different levels of the specified explanatory factor with adjustment for all other factors in the multivariable model. The threshold for statistical significant was 0.05.

^dThe Ptrend (two-sided) is from the test for trend, where the threshold for statistical significant was 0.05.

^eDegree received at age 16.

^fDegree received at age 18.