Table 2. DII and breast cancer risk by menopausal status.
| Quartile 1 <1.87 Median=1.01 N=11 314 | Quartile 2 1.87–2.92 Median-2.45 N=11 315 | Quartile 3 2.93–3.77 Median=3.36 N=11 313 | Quartile 4 >3.77 Median=4.24 N=11 315 | P-valuea | DII continuous | |
|---|---|---|---|---|---|---|
| Cases/person years | 454/203 583 | 493/204 109 | 468/203 472 | 480/203 050 | 1895/81 4214 | |
|
Overall | ||||||
| Model 1b (HR, 95% CI) | 1a | 1.09 (0.96, 1.24) | 1.05 (0.93, 1.20) | 1.08 (0.95, 1.22) | 0.32 | 1.02 (0.98, 1.01) |
| Model 2c (HR, 95% CI) | 1a | 1.11 (0.97, 1.23) | 1.10 (0.95, 1.23) | 1.18 (1.00, 1.39) | 0.07 | 1.04 (1.01, 1.09) |
|
Menopausal status | ||||||
| Pre | ||||||
| Model 1b (HR, 95% CI) | 1a | 0.92 (0.69, 1.22) | 0.77 (0.56, 1.05) | 0.96 (0.68, 1.34) | 0.45 | 0.94 (0.86, 1.02) |
| Model 2c (HR, 95% CI) | 1a | 0.93 (0.70, 1.24) | 0.76 (0.55, 1.04) | 0.96 (0.68, 1.35) | 0.43 | 0.93 (0.86, 1.02) |
| Post | ||||||
| Model 1b (HR, 95% CI) | 1a | 1.17 (1.00, 1.37) | 1.20 (1.02, 1.41) | 1.22 (1.02, 1.47) | 0.02 | 1.07, 1.02, 1.12 |
| Model 2c (HR, 95% CI) | 1a | 1.17 (1.00, 1.36) | 1.18 (1.00, 1.40) | 1.22 (1.02, 1.46) | 0.03 | 1.07, 1.02, 1.12 |
Abbreviations: BMI=body mass index; CI=confidence interval; DII=dietary inflammatory index; HR=hazard ratio.
a
P-value for trend determined through the median approach.
b
Model 1: Age-adjusted.
c
Model 2: Adjusted for energy, age at first birth and number of children, age at menarche, BMI, height, multivitamin use, education, smoking status, oral contraceptive use, and family history of breast cancer in the model.