. 2013 Dec 16;35(2):275–282. doi: 10.1038/aps.2013.146

Table 2. Pharmacokinetic parameters of tolsultazolamide in rats after oral administration at three different doses. n=6. Mean±SD. ^cP<0.01 among the three groups.

Parameters	20 mg/kg	40 mg/kg	80 mg/kg
k_e (1/h)	0.122±0.059	0.115±0.036	0.154±0.046
T_1/2 (h)	6.8±3.1	6.6±2.4	4.8±1.3
T_max (h)	2.2±0.5	2.1±0.6	1.8±0.5
C_max (μg/mL)	0.523±0.213	0.710±0.245	1.626±0.266^c
AUC_0–t (h·μg/mL)	2.730±1.290	5.580±1.839	11.438±1.637^c
AUC_0–∞ (h·μg/mL)	3.893±2.024	6.004±1.796	12.278±2.533^c
V_d/F (L/kg)	60.019±37.779	71.526±45.825	45.925±12.909
CL/F (L·h⁻¹·kg⁻¹)	6.444±3.352	7.174±2.106	6.740±1.324
MRT (h)	4.8±0.3	8.4±0.9	7.5±1.3

Table 2. Pharmacokinetic parameters of tolsultazolamide in rats after oral administration at three different doses. n=6. Mean±SD. cP<0.01 among the three groups.