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DZ2002 treatment modulated serum anti-dsDNA autoantibodies and cytokines in NZB/W F1 mice. At the termination of treatment, serum of female NZB/W F1 mice were collected and examined for anti-dsDNA autoantibodies and cytokines. (A) Serum levels of anti-dsDNA total IgG, IgG1, IgG2a, and IgG3 antibodies. (B) Serum levels of IL-17A, TGF-β, IL-23p19, and IL-12p40. Mean±SEM. n=8 for each group, each symbol represented an individual mouse. bP<0.05, cP<0.01 vs vehicle.
