Table 1.
Characteristics of the subvolumes of the ear (140 patients), the pituitary gland and hypothalamus (103 adults + 26 children) with and without complications (73/280 cases with hearing late effects, 10/26 children and 45/103 adults with endocrinopathy)
| Organ at risk | Number of structures | Volume (cm3) | Mean dose (Gy-RBE) without toxicity | Mean dose (Gy-RBE) with toxicity (any end point) |
|---|---|---|---|---|
| Inner ear | 280 | 2.80 ± 1.0 (1.20–5.10) | 35.0 ± 14.0 (0.6–61.0) | 54.0 ± 11.0 (30.6–73.3) |
| Cochlea | 138 | 0.11 ± 0.07 (0.03–0.36) | 36.8 ± 14.0 (0.5–62.6) | 54.6 ± 16.0 (4.7–72.8) |
| Internal auditory canal | 133 | 0.22 ± 0.07 (0.07–0.35) | 42.0 ± 16.0 (0–71.2) | 54.0 ± 15.0 (0.3–73.7) |
| Pituitary gland (adults) | 103 | 0.38 ± 0.20 (0.06–0.90) | 46.7 ± 20.0 (1.8–68.3) | 63.5 ± 6.8 (34.0–72.8) |
| Pituitary gland (children) | 26 | 0.30 ± 0.10 (0.10–0.50) | 42.9 ± 27.0 (2.0–69.9) | 55.6 ± 10.8 (39.7–71.5) |
| Hypothalamus (children) | 22 | 0.40 ± 0.10 (0.10–0.70) | 31.2 ± 21.6 (1.4–64) | 39.7 ± 14.0 (13.0–54.8) |
Data are expressed as mean ± standard deviation (minimum–maximum).