Fig 2. Predicted coevolving residue pairs within V3.

TP predicted coevolving pairs are connected with a green dash and the FP ones are shown as red bonds. Amino acid numbering is according the HXB2 reference sequence and the V3 coordinate structure solved by Huang et al. [11] is applied for visualisation. (A) Travers and co-authors [42] identified 24 coevolving pairs of which the majority is FP. (B) Coevolution predictions made by GREMLIN identified almost exclusively TP.