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. 2015 Nov 18;10(11):e0143436. doi: 10.1371/journal.pone.0143436

Table 3. List of enriched functional annotation groups in 8 clusters by functional annotation clustering analysis.

Cluster Description for Functional Annotation Groups Enrichment Score* No of Genes
1 1. Blood vessel development/morphogenesis 6.211 24
2. Ion/cellular chemical homeostasis 4.421 27
3. Positive regulation of protein modification/positive regulation of phosphate (phosphorous) metabolic process 4.26 14
4. Positive regulation of (cellular) proteinmetabolic process 3.464 18
5. Regulation of apoptosis/programmed cell death 3.354 25
6. Regulation of axonogenesis/neuron differentiation 2.015 8
7. Negative regulation of axonogenesis/neurogenesis 1.515 5
8. Negative regulation of apoptosis/programmed cell death 1.486 17
9. Gonad development/ovulation cycle process 1.37 7
10. Mesenchymal cell differentiation/development 1.347 5
2 1. Negative regulation of cellular biosynthetic process/cellular metabolic process 4.926 61
2. Negative regulation of transcription/RNA metabolic process 4.269 45
3. Neuron projection development/cell morphogenesis 2.903 30
4. Regulation of biosynthetic process/transcription 1.92 161
5. Blood vessel development/morphogenesis 1.532 21
6. Cellular protein catabolic process/proteolysis 1.53 54
7. Positive regulation of cellular metabolic process/biosynthetic process/transcription 1.456 59
8. Mesenchymal cell differentiation/development 1.446 7
3 1. Complement activation/B cell mediated immunity 1.6 6
2. Positive regulation of protein modification/phosphate (phosphorous) metabolic process 1.464 13
3. Negative regulation of apoptosis/programmed cell death 1.39 21
4 1. Nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process/nucleoside phosphate metabolic process 3.17 21
2. Proton transport/ATP synthesis coupled proton Transport/ion transmembrane transport 3.156 10
3. Positive regulation of ion transport/regulation of metal ion transport 2.54 10
4. Cellular response to starvation/nutrient levels 1.873 6
5. Negative regulation of apoptosis/programmed cell death 1.627 22
5 1. RNA processing/RNAsplicing 22.144 76
2. Regulation of gene expression/ macromolecule biosynthetic process 5.364 221
3. Nucleic acid transport/mRNA transport 2.751 15
4. Negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process/ macromolecule metabolic expression/transcription process/gene 2.132 58
5. Cellular glucan metabolic process/polysaccharide metabolic process/energy reserve metabolic process 2.084 8
6 1. M phase/mitosis 3.506 28
2. Nucleic acid transport/mRNA transport 3.397 13
3. tRNA aminoacylation for protein translation/cellular amine metabolic process 1.887 12
4. Modification-dependent macromolecule catabolic process/protein catabolic process 1.656 35
7 1. Protein amino acid glycosylation/glycoprotein biosynthetic process 2.882 16
2. Modification-dependent macromolecule catabolic process/protein catabolic process 1.478 37
8 1. Blood vessel development/differentiation 2.862 21
2. Neuron projection development/cell morphogenesis 2.222 23
3. Positive regulation of cell migration/cell motion 1.723 11

*; Functional annotation groups resulted from functional annotation clustering analysis using BP terms were ordered by their mean enrichment score. And, it was considered as significant functional groups that were over 1.3 of enrichment score. Gene symbols used in functional annotation clustering analysis were human orthologues corresponding to probe identifications of Porcine Genome Array.