Table 2. Logistic regression analysis of the presence of SLI, MS-cWMH, LCAS, ICAS, and ECAS in 1,011 Korean participants according to serum ALP tertile.
| SLI | MS-cWMH | LCAS | ICAS | ECAS | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |
| Unadjusted | ||||||||||
| 1st tertile (≤ 155 IU/L) | Ref | Ref | Ref | Ref | Ref | |||||
| 2nd tertile (156–194 IU/L) | 1.31 (0.78–2.19) | 0.306 | 1.09 (0.77–1.53) | 0.640 | 1.18 (0.80–1.74) | 0.392 | 1.26 (0.76–2.10) | 0.373 | 0.97 (0.61–1.55) | 0.912 |
| 3rd tertile (≥ 195 IU/L) | 2.11 (1.31–3.41) | 0.002 | 1.63 (1.17–2.27) | 0.004 | 1.15 (0.78–1.69) | 0.483 | 1.21 (0.72–2.02) | 0.468 | 0.94 (0.59–1.50) | 0.783 |
| Adjusted* | ||||||||||
| 1st tertile (≤ 155 IU/L) | Ref | Ref | Ref | Ref | Ref | |||||
| 2nd tertile (156–194 IU/L) | 1.34 (0.79–2.26) | 0.280 | 1.03 (0.71–1.51) | 0.870 | 1.21 (0.81–1.82) | 0.352 | 1.29 (0.76–2.19) | 0.340 | 0.97 (0.60–1.56) | 0.894 |
| 3rd tertile (≥ 195 IU/L) | 2.09 (1.27–3.42) | 0.004 | 1.48 (1.03–2.13) | 0.036 | 1.13 (0.75–1.69) | 0.568 | 1.11 (0.66–1.89) | 0.694 | 0.92 (0.57–1.51) | 0.751 |
*Adjusted for age, gender, hypertension, diabetes, hyperlipidemia, coronary artery occlusive disease, and smoking.
Ref, reference group for statistical analysis; ALP: Alkaline phosphatase; SLI, silent lacunar infarct; MS-cWMH, moderate-to-severe cerebral white matter hyperintensities; LCAS, large cerebral arterial stenosis; ICAS, intracranial arterial stenosis; ECAS, extracranial arterial stenosis; OR, odds ratio; CI: confidence interval.