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. Author manuscript; available in PMC: 2016 Sep 18.
Published in final edited form as: J Org Chem. 2015 Sep 4;80(18):9279–9291. doi: 10.1021/acs.joc.5b01765

Table 1.

IC50 values of ipomoeassin A–F.

graphic file with name nihms721006t1.jpg Ipomoeassin Structure
IC50 (nM)
R1 R2 n HeLa L-929 A2780 U937 HT-29 MDA-
MB-435
H522-T1

A H Ac 1 64 77.8 500 20.2 46.1 42.6 108.9
B H H 1 2500 400 134 396 2700 1070
C OH Ac 1 1500 > 1000 2900

D OAc Ac 1 32 135 35 7.9 11.8 19.9 23.2

E OAc H 1 4300 > 1000 3300 163 393 1633 967

F H Ac 3 7.4 36 2.6 4.2 9.4 12.9