(a) Control A431 cells (shCtl), MALT1 knockdown cells (shMALT1), and control cells treated with MALT1 inhibitor z-VRPR-Fmk (75uM) were stimulated with EGF (100ng/ml), respectively. Total RNA was extracted for quantitative PCR analysis. The ratio of mRNA of human IL-6 to human HPRT1 were calculated and compared in the graph. *, p<0.05. (b) Total RNA was extracted from control (shCtl) HCC827 cells, MALT1 knockdown cells (shMALT1), and control cells treated with MALT1 inhibitor z-VRPR-Fmk (75μM), respectively. The ratio of mRNA of human IL-6 to human HPRT1 were calculated and compared in the graph. *, p<0.05. (c) Total RNA was extracted from the lung of tetO-EGFRL858R; CCSP-rtTA; MALT1+/− and tetO-EGFRL858R; CCSP-rtTA; MALT1−/− mice. The ratio of IL-6 to GAPDH was presented in the graph. *, p<0.05. (d) The working model summarizing the finding in this study.