5 % Weight Loss N=598	95% CI	No Change in Weight N=916	95% CI	5 % Weight Gain N=215	95% CI
Short-Form 12 Score
Overall Score	OA+	99.7	98.7–100.7	100.5	99.7–101.4	97.7	95.9–99.4
	OA−	103.5	102.5–104.5	101.2	99.2–103.2	101.8	100.6–103.1
Physical	OA+	45.1	44.2–45.9	45.2	44.5–45.9	43.2	41.8–44.8
	OA−	48.0	46.9–49.0	48.5	47.6–49.3	46.4	44.8–48.2
Mental	OA+	54.6	53.8–55.3	55.4	54.8–56.0	54.4	53.1–55.6
	OA−	53.9	52.9–54.8	55.1	54.4–55.8	54.5	52.9–56.0
Physical Activity Scale for Elderly	OA+	119.1	113.5–124.7	125.8	121.3–130.4	108.6	99.1–118.2
	OA−	127.7	120.0–135.4	127.9	121.8–134.0	125.7	113.3–138.2
Late-Life Disability Index
Frequency	OA+	54.6	54.0–55.2	55.4	54.9–55.9	54.6	53.6–55.7
	OA−	55.0	54.2–55.8	56.3	55.6–56.9	55.1	53.8–56.4
Limitation	OA+	79.4	77.9–80.9	80.9	79.7–82.1	77.1	74.5–79.6
	OA−	81.3	79.3–83.2	82.7	81.1–84.3	80.2	77.0–83.4
Gait Speed	OA+	1.21	1.19–1.23	1.22	1.21–1.23	1.16	1.14–1.19
	OA−	1.26	1.24–1.29	1.27	1.25–1.28	1.24	1.21–1.27
Chair Stand	OA+	0.49	0.48–0.51	0.49	0.48–0.50	0.48	0.46–0.50
	OA−	0.52	0.50–0.54	0.52	0.51–0.54	0.51	0.48–0.54

OA + : radiographic knee osteoarthritis present; OA − : radiographic knee osteoarthritis absent

Values represent mean score (95% confidence interval) of the indicated metric adjusted for: Age, sex, education level, race, Charlson co-morbidity index, smoking status, hip pain and cohort type (incidence, progression), and baseline scoring (Short Form 12, Physical Activity Scale for the Elderly) where available. Models stratified by age adjust for the similar co-variates other than age.

Cohort included in the modeling includes all eligible subjects with follow-up data on outcomes of Short Form 12, Physical Activity Scale for the Elderly and Late-Life Function and Disability Instrument (n=1,729)