Table 1.
Clinical characteristics of study participants
| African American Discovery | African American Replication | African American Extension | European American | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable | T2D-ESKD cases | Population-based controls | T2D-ESKD cases | Population-based controls | Non-diabetic ESKD cases | T2D non-nephropathy controls | T2D-ESKD cases | Population-based controls | T2D non-nephropathy controls |
| Sample size (N) | 965 | 1029 | 1312 | 774 | 1523 | 555 | 604 | 1030 | 625 |
| Female (%) | 61.2 | 57.3 | 60.7 | 57.9 | 43.7 | 57.1 | 49.5 | 63.8 | 54.9 |
| Age (years) | 61.6 ± 10.5 | 49.0 ± 11.9 | 61.3 ± 10.8 | 48.4 ± 12.7 | 54.6 ± 14.6 | 55.6 ± 9.7 | 65.3 ± 10.4 | 53.9 ± 15.1 | 63.1 ± 9.1 |
| Age at T2D (years) | 41.6 ± 12.4 | - | 41.3 ± 12.4 | - | - | 45.6 ± 10.0 | 45.4 ± 13.6 | - | 51.9 ± 9.2 |
| ESKD Duration (years) |
3.65 ± 4.2 | - | 3.66 ± 3.9 | - | 2.2 ± 1.64 | - | 2.6 ± 3.0 | - | - |
| Glucose (mg/dl) | - | 88.8 ± 13.1 | - | 89.2 ± 13.6 | 88.6 ± 8.66 | - | - | 93.1 ± 16.9 | 148.2 ± 55.7 |
| BMI (at recruitment; kg/m2) |
29.7 ± 7.0 | 30.0 ± 7.0 | 30.3 ± 7.2 | 29.2 ± 7.4 | 27.2 ± 6.98 | 36.3 ± 17.4 | 29.6 ± 7.1 | 28.4 ± 5.7 | 32.8 ± 7.1 |
| Serum creatinine (mg/dl) |
- | 0.99 ± 0.25 | - | 1.03 ± 0.46 | - | 0.97 ± 0.28 | - | 0.96 ± 0.5 | 1.03 ± 0.26 |
| African Ancestry proportion (%) |
79.9 | 78.2 | 79.9 | 78.3 | 80 | 76.9 | - | - | - |
Continuous data presented as mean ± SD