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. Author manuscript; available in PMC: 2016 Dec 30.
Published in final edited form as: J Neurosci Methods. 2015 Aug 24;256:56–62. doi: 10.1016/j.jneumeth.2015.08.017

Figure 2. Effect of the A1 agonist, cyclopentyladenosine (CPA) on adenosine release.

Figure 2

(A) Representative traces and 2D color plots depicting the detection of adenosine in the dorsal striatum before (left) and after (right) CPA (2 mg/kg, i.p.) administration. Stars on top of spikes indicate that the obtained cyclic voltammogram has characteristics of adenosine detection. (B) The average amplitude was obtained from all spikes detected per rat for 10 s across four rats before and 30 min after the drug. Neither CPA nor saline (vehicle control) administration affect the amplitude of striatal adenosine transients. (C) CPA administration results in a significant reduction in adenosine spike frequency. **P < 0.01, paired t-test. Data are means ± SEM of four rats per group.