Table 2.
Intrinsic connectivity correlates for different types of anxiety
| Anxiety Phenotype/Clinical Measure | Seed | Region of interest (x/y/z) | Cluster size (ke), t statistic, degrees of freedom |
|---|---|---|---|
|
| |||
| Global Anxiety/HARS | Bed Nucleus of Stria Terminalis | Left Frontal (BA 6) (−32/1/55) | (510, 3.570, 52) |
| Left Middle Temporal (−50/−52/4) | (181, 3.694, 52) | ||
|
| |||
| Left Amygdala | Left Hippocampus (−18/−40/8) | (607, 3.870, 52) | |
| Left Middle Frontal Gyrus (−38/4/58) | (36, 3.640, 52) | ||
|
| |||
| Paraventricular Nucleus | Left Caudate (tail) (−28/−38/8) | (4378, 4.521, 52) | |
| Left Hippocampus (−26/−38/3) | (4378, 4.427, 52) | ||
| Left Parietal (BA2) (−37/−30/32) | (4378, 5.103, 52) | ||
|
| |||
| Posterior Cingulate Cortex | Right Middle Temporal (BA22) (54/−42/4) | (1413, 4.890, 52) | |
|
| |||
| Ventral Hippocampus | Left Middle Temporal Gyrus (BA22) (−60/−48/2) | (76, 3.633, 52) | |
| Left Dorsal Hippocampus (−23/−40/0) | (144, 3.724, 52) | ||
|
| |||
| Somatic anxiety/HARS-S | Bed Nucleus of Stria Terminalis | Left Middle Temporal (BA21) (−57/−24/−7) | (509, 4.378, 52) |
| Left Inferior Temporal (−50/−54/−8) | (509, 4.217, 52) | ||
|
| |||
| Left Amygdala | Right Dorsal Hippocampus (−12/−38/10) | (288, 4.068, 52) | |
| Left Dorsal Hippocampus (−13/−36/5.6) | (323, 3.811, 52) | ||
|
| |||
| Paraventricular Nucleus | Left Hippocampus (−23/−40/0) | (1814, 4.681, 52) | |
| Left Caudate (tail) (−28/−38/8) | (1814, 4.681, 52) | ||
| Left Cingulate (BA31) (−18.7/−34/39) | (421, 4.39, 52) | ||
|
| |||
| Posterior Cingulate Cortex | Right Insula (BA 13) (44/−14/−2) | (2180, 4.901, 52) | |
| Right Amygdala (24/0/−16) | (77, 4.391, 52) | ||
| Right Superior Temporal Gyrus (BA 22) (55/−32/2) | (2180, 5.260, 52) | ||
|
| |||
| Ventral Hippocampus | Right Temporal Inferior (42/−64/−6) | (99, 3.577, 52) | |
|
| |||
| Worry/PSWQ | Right Anterior Insula | Left cuneus (0/−84/38) | (848, 4.011, 52) |
| Right precuneus (BA 31) (12/−56/32) | (848, 3.836, 52) | ||
| Right precuneus (BA19) (34/−78/37) | (69, 3.94, 52) | ||
|
| |||
| Neuroticism/FFI-N | Left Amygdala | Right Caudate (16/6/21) | (1772, 4.322, 52) |
| Dorsal ACC (BA 32) (12/24/26) | (1772, 3.916, 52) | ||
| Left dlPFC (BA 46) (−46/32/23) | (458, 3.654, 52) | ||
| Right Insula/Frontal Operculum (34/25/8) | (944, 5.25, 52) | ||
| Right Fusiform Gyrus (BA 19) (30/−50/−7) | (268, 3.479, 52) | ||
|
| |||
| Paraventricular Nucleus | Left Fusiform Gyrus (BA 37) (−34/−40/−15) | (148, 4.271, 52) | |
|
| |||
| Ventral Hippocampus | Right Caudate Head (15/10/17) | (1507, 4.128, 52) | |
| Middle Frontal Gyrus (36/4/58) | (26, 3.623, 52) | ||
| Inferior Frontal Gyrus (42/32/10) | (230, 3.595, 52) | ||
Clinical measures: Penn State Worry Questionnaire (PSWQ), Hamilton Anxiety Rating Scale (HARS), Hamilton Anxiety Rating Scale - Somatic (HARS-S), Five Factor Inventory – Neuroticism (FFI-N)