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. Author manuscript; available in PMC: 2016 Nov 15.
Published in final edited form as: Cancer Res. 2015 Oct 2;75(22):4688–4696. doi: 10.1158/0008-5472.CAN-15-0892

Figure 1. RT induces increased expression of the androgen receptor.

Figure 1

(A) LNCaP, LNCaP-AR, MDA-PCa2b, and CWR22Pc cell lines were treated with either 0, 1, 6, or 12 Gy or EBRT and the cells harvested for mRNA measured by qPCR, and (B) protein by western blot.

(C) LNCaP-AR derived xenografts were treated with 10 Gy of conformal EBRT and compared to non-irradiated controls, and mRNA for AR was measured by qPCR, and (D) protein by western blot.

(E) LNCaP-AR xenografts were treated with 10 Gy of EBRT and harvested 5 days after treatment, fixed and formalin and paraffin embedded and stained by IHC and immunofluorescence for AR.

Significance level indicated by * (p<0.05) or p-value listed in figure.