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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2015 Oct 3;289(2):155–162. doi: 10.1016/j.taap.2015.09.029

Scheme 1. Chemistry of MG-Arginine Adduction.

Scheme 1

MG primarily reacts with arginine residues to form neutral ring structures- MG-DH (dihydroxyimidazolidine, R+72) and MG-HI (hydroimidazolone, R+54).