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Published in final edited form as: Neuroimage. 2015 Jun 30;124(0 0):1155–1167. doi: 10.1016/j.neuroimage.2015.06.065

(A) Project, containing description of the research project for which data are collected. Currently 4 projects from 3 data sources are included in the domain model. (B) Subject, containing demographic and diagnostic information for individual participants of the project. “Subject” is subsequently defined by “minimum age,” “maximum age,” “sex,” and “diagnosis.” Current diagnosis categories are: “no known disorder” (for healthy controls), “bipolar disorder,” “schizophrenia broad,” which includes “schizophrenia strict” and “schizoaffective.” We note that the precise definition of “control” may depend on specific studies and study populations, we did not use the term “control” to label the healthy comparison subjects provided by each data source. Instead, the term “no known disorders” is used. (C) Imaging_Protocol (MRI), containing information on MRI scanner platforms and imaging protocols under which subject imaging data were collected. “Imaging protocol” is subsequently defined by “structural,” “functional,” “perfusion,” and “field mapping.” Both “structural” and “functional” protocols are subdivided for further distinctions including “T1,” “T2,” “resting state,” and “task paradigm.” (D) Cognitive domain contains neuropsychological assessments. The domain model uses the MATRICS Consensus Cognitive Battery (Nuechterlein et al., 2008) terms whenever appropriate, which are “attention,” “executive function,” “learning,” “working memory,” “episodic memory,” “intelligence,” “language,” “motor,” “premorbid functioning,” “processing speed,” “social cognition,” and “visuospatial.” (E) Clinical domain contains full demographics, assessments of symptoms and functional capacity, and medical information. Demographics information includes “Race,” “Ethnicity,” “Education,” “SES (socioeconomic status),” and “Handedness.” Symptom measures include “PANSS (Positive And Negative Symptoms Scales),” “SAPS (Scale for the Assessment of Positive Symptoms),” “SANS (Scale for the Assessment of Negative Symptoms),” using the Unified Medical Language System (UMLS) terms whenever appropriate. Symptom measures also include “Depression,” “Mood,” “Suicide Ideation,”, and “Extrapyramidal Symptoms.” Medical information includes “Medical History/Medication,” “SCID (Structured Clinical Interview for DSM Disorders),” and “Nicotine Addiction/Dependence.”

(G) Examples of inter-schema mappings. For example, subject data for the NUSDAST source is obtained by calling the XNAT search web service and joining with a diagnostic code mapping table to harmonize the diagnoses; normalized diagnosis of Strict Schizophrenia for the subjects in the HID source is computed on the fly, by first joining three HID tables with subject and assessment data, then selecting the subjects according to a predefined algorithm on assessment values.

(A) Project, containing description of the research project for which data are collected. Currently 4 projects from 3 data sources are included in the domain model. (B) Subject, containing demographic and diagnostic information for individual participants of the project. “Subject” is subsequently defined by “minimum age,” “maximum age,” “sex,” and “diagnosis.” Current diagnosis categories are: “no known disorder” (for healthy controls), “bipolar disorder,” “schizophrenia broad,” which includes “schizophrenia strict” and “schizoaffective.” We note that the precise definition of “control” may depend on specific studies and study populations, we did not use the term “control” to label the healthy comparison subjects provided by each data source. Instead, the term “no known disorders” is used. (C) Imaging_Protocol (MRI), containing information on MRI scanner platforms and imaging protocols under which subject imaging data were collected. “Imaging protocol” is subsequently defined by “structural,” “functional,” “perfusion,” and “field mapping.” Both “structural” and “functional” protocols are subdivided for further distinctions including “T1,” “T2,” “resting state,” and “task paradigm.” (D) Cognitive domain contains neuropsychological assessments. The domain model uses the MATRICS Consensus Cognitive Battery (Nuechterlein et al., 2008) terms whenever appropriate, which are “attention,” “executive function,” “learning,” “working memory,” “episodic memory,” “intelligence,” “language,” “motor,” “premorbid functioning,” “processing speed,” “social cognition,” and “visuospatial.” (E) Clinical domain contains full demographics, assessments of symptoms and functional capacity, and medical information. Demographics information includes “Race,” “Ethnicity,” “Education,” “SES (socioeconomic status),” and “Handedness.” Symptom measures include “PANSS (Positive And Negative Symptoms Scales),” “SAPS (Scale for the Assessment of Positive Symptoms),” “SANS (Scale for the Assessment of Negative Symptoms),” using the Unified Medical Language System (UMLS) terms whenever appropriate. Symptom measures also include “Depression,” “Mood,” “Suicide Ideation,”, and “Extrapyramidal Symptoms.” Medical information includes “Medical History/Medication,” “SCID (Structured Clinical Interview for DSM Disorders),” and “Nicotine Addiction/Dependence.”

(G) Examples of inter-schema mappings. For example, subject data for the NUSDAST source is obtained by calling the XNAT search web service and joining with a diagnostic code mapping table to harmonize the diagnoses; normalized diagnosis of Strict Schizophrenia for the subjects in the HID source is computed on the fly, by first joining three HID tables with subject and assessment data, then selecting the subjects according to a predefined algorithm on assessment values.