Table 2.
Effect of genotype on lumbar vertebral bone volume and on cancellous bone volume fraction (bone volume/tissue volume) and cancellous bone architecture in vertebral body.
| WT | ob/+ | ob/ob | ANOVA Pc | |
|---|---|---|---|---|
|
|
||||
| Total Vertebra | ||||
| Bone volume (mm3) | 2.9 ± 0.1 | 3.6 ± 0.1a | 3.1 ± 0.2b | 0.001 |
| Vertebral Body (cancellous bone) | ||||
| Bone volume/tissue volume (%) | 15.6 ± 0.4 | 15.2 ± 0.8 | 18.2 ± 0.7a,b | 0.018 |
| Connectivity density (mm−3) | 252 ± 9 | 249 ± 13 | 354 ± 11a,b | 0.000 |
| Trabecular number (mm−1) | 5.3 ± 0.1 | 5.2 ± 0.1 | 5.9 ± 0.2a,b | 0.001 |
| Trabecular thickness (μm) | 38 ± 0 | 39 ± 1 | 38 ± 1 | 0.333 |
| Trabecular spacing (μm) | 186 ± 2 | 191 ± 3 | 167 ± 5a,b | 0.002 |
Data are mean ± SE
c
The Benjamini and Hochberg method for maintaining the false discovery rate at 5% was used to adjust for multiple comparisons
a
Different from WT, P < 0.05;
b
Different from ob/+, P < 0.05