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. Author manuscript; available in PMC: 2016 Nov 17.
Published in final edited form as: Circulation. 2015 Sep 10;132(20):1880–1890. doi: 10.1161/CIRCULATIONAHA.115.016160

Figure 4.

Figure 4

Neutralizing IL-1β changes the bone marrow microenvironment and dampens progenitor release after MI. (a) mRNA quantification of HSC retention factors (CXCL12, chemokine (C-X-C motif) ligand 12, VCAM-1, vascular cell adhesion molecule 1; SCF, stem cell factor and OPN, osteopontin) in flushed bone marrow with qRT-PCR 48h after MI (n = 6 per group, one-way ANOVA). (b) LSK numbers in the blood 4d after MI (n = 5–6 per group). (c) Splenic LSK and GMP (granulocyte-macrophage progenitors), 7d after MI (n = 9–11 per group, mean ± SD, *p<0.05, **p<0.01, Mann-Whitney test).