Neutralizing IL-1β changes the bone marrow microenvironment and dampens progenitor release after MI. (a) mRNA quantification of HSC retention factors (CXCL12, chemokine (C-X-C motif) ligand 12, VCAM-1, vascular cell adhesion molecule 1; SCF, stem cell factor and OPN, osteopontin) in flushed bone marrow with qRT-PCR 48h after MI (n = 6 per group, one-way ANOVA). (b) LSK numbers in the blood 4d after MI (n = 5–6 per group). (c) Splenic LSK and GMP (granulocyte-macrophage progenitors), 7d after MI (n = 9–11 per group, mean ± SD, *p<0.05, **p<0.01, Mann-Whitney test).