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. 2015 Nov 5;2015:279591. doi: 10.1155/2015/279591

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Copyright © 2015 Simon J. Hogg et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

The effects of cellular metabolism, growth activity, and modulation of selective proteins following treatment of resveratrol, acetyl-resveratrol, and polydatin in OVCAR-8 spheroids. Resveratrol (a) and acetyl-resveratrol (b) reduced cellular metabolism in a dose-dependent manner. Higher concentrations of both these compounds also reduced growth activity (d and e). Polydatin showed limited effects (c and f). Both resveratrol (g) and acetyl-resveratrol (h) induced the increased expression of 89 kDa PARP-1. The activation of Erk was increased following 5 and 10 μ resveratrol and acetyl-resveratrol exposure. ∗ refers to statistically significant as p value less than 0.05 compared to the control.