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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Cancer Chemother Pharmacol. 2015 Oct 29;76(6):1297–1307. doi: 10.1007/s00280-015-2879-4

Figure 1. Anthracyclines induce cytotoxic changes in cardiac tissue and increase ROS levels in monocytes. Doxorubicin cumulative dose is correlated with ROS levels.

Figure 1

A) Mice were treated with placebo (n=5) or DOX (n=5) on days 0, 14 and 28 and were sacrificed at day 36. B) Hematoxylin and Eosin staining of the left ventricular myocardium was performed. In the placebo group (left) 0/5 mice had identifiable histologic lesions in the heart. In the DOX treated group (right) 2/4 mice had histologic lesions consistent of change in striation and signs of necrosis. C) ROS levels were quantified by HE assay (measure of superoxide levels) and results expressed as Mean Fluorescence Intensity. DOX treated mice showed more than double ROS levels compared to PBS treated mice and this finding was statistically significant. ** p < 0.01.