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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Cancer Chemother Pharmacol. 2015 Oct 29;76(6):1297–1307. doi: 10.1007/s00280-015-2879-4

Figure 2. Acute leukemia cells are slightly more sensitive to anthracyclines. Viability decreases and DNA fragmentation increases at 24 hours in acute leukemia cells and cardiomyocytes.

Figure 2

Jurkat (derived from patient with T-cell ALL) and ML-1 (derived from a patient with M5 AML) and cardiomyocyte H9C2 cell lines were treated with increasing doses of A) DOX and B) DNR (0.5 µM–3 µM) for 24 hours. Cell viability was quantified by trypan blue exclusion using a Vi-cell analyzer. Subsequently, Jurkat (C and D), ML-1 cells (E and F) were treated with DOX (2 µM) and DNR (1 µM) and H9C2 (G and H) were treated with 25 µM of DOX and DNR for different time points and viability and DNA fragmentation were assessed, respectively. The results represent the mean ± SEM of 3 different experiments.