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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Cancer Chemother Pharmacol. 2015 Oct 29;76(6):1297–1307. doi: 10.1007/s00280-015-2879-4

Figure 4. Glutathione levels (GSH) do not significantly change before cell death in anthracycline treated acute leukemia cells and cardiomyocytes. GSH events are independent of caspase regulation in acute leukemia cells.

Figure 4

Jurkat, ML-1 and H9C2 cells were treated at 8 hours with A) DOX and B) DNR and GSH levels were measured by spectrofluorometry. Results were normalized to control. Jurkat and ML-1 cells were pretreated with pancaspase inhibitor Z-vad-fmk (20 µM) and then exposed to anthracyclines for 24 hours. GSH levels were measured by spectrofluorometry and results were normalized to control. Results represent the mean ± SEM of 3 different experiments.