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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2015 Sep 30;289(2):213–222. doi: 10.1016/j.taap.2015.09.022

Figure 1. AMAP induces cell death and GSH depletion in human hepatocytes.

Figure 1

Primary human hepatocytes (PHH) were treated with 10 mM of AMAP or APAP over a period of 48 h, and the percentage of alanine aminotransferase (ALT) release was measured at 24 h (A) and 48 h (B) to evaluate toxicity. (C) Dose-response of AMAP toxicity at 48 h after treatment. (D) Glutathione depletion after 10 mM AMAP or APAP exposure for 24 h. Data represent mean ± SE from experiments using cells from 3 to 10 donors. *P< 0.05 (compared with controls); #P< 0.05 (compared with APAP group).