. Author manuscript; available in PMC: 2016 Dec 1.

Published in final edited form as: Clin Exp Metastasis. 2015 Oct 7;32(8):799–817. doi: 10.1007/s10585-015-9752-z

Table 2. Cellular mechanistic IC₅₀ values for OXA-11 inhibition of FAK in cell lysates from five species.

Species	Cell line	OXA-11 IC₅₀ (nM) for FAK
Mouse	4T1 mammary carcinoma cells	8
Rat	RMC kidney mesangial cells	18
Human	MDA-MB-361 breast adenocarcinoma metastasis cells	20
Dog	MDCK kidney epithelial cells	32
Monkey	CMMT mammary gland epithelial cells	84

Cell-based kinase assays were done to determine the IC₅₀ values (nM) for OXA-11 inhibition of FAK kinase in cell lysates using Omnia Kinase Assays (Invitrogen)

Table 2. Cellular mechanistic IC50 values for OXA-11 inhibition of FAK in cell lysates from five species.

Table 2. Cellular mechanistic IC₅₀ values for OXA-11 inhibition of FAK in cell lysates from five species.