Table 3.
Parameter estimates for multivariable models of plasma IGF-1 and IGFBP-3.
| logIGF-1 | P | logIGFBP-3 | P | |
|---|---|---|---|---|
| Age | NS | -- | −0.0068 | <0.0001 |
| Female | NS | -- | NS | -- |
| Smoking | NS | -- | NS | -- |
| BMI | 0.010 | 0.010 | 0.010 | 0.003 |
| Diabetes | −0.17 | 0.013 | NS | -- |
| Cirrhosis | −0.61 | <0.0001 | −0.76 | <0.0001 |
| Sepsis/septic shock | NS | -- | −0.19 | 0.009 |
| Pneumonia/aspiration | NS | -- | NS | -- |
| APACHE III | −0.0064 | <0.0001 | NS | -- |
| ARDS | −0.22 | 0.0005 | −0.19 | 0.0004 |
| Adjusted R-square | 0.145 | -- | 0.160 | -- |
Cells show parameter estimates (β) except as noted. IGF-1 is measured in ng/mL; IGFBP-3 is measured in ug/mL. NS = not significant (variables that did not survive the selection algorithm prior to model refit); BMI = body mass index; ARDS = acute respiratory distress syndrome; APACHE = Acute Physiology, Age and Chronic Health Evaluation.