Table 4.
Parameter estimates for multivariable models of plasma IGF-1 and IGFBP-3, including genotype at rs2854746 (IGFBP3).
| logIGF-1 | P | logIGFBP-3 | P | |
|---|---|---|---|---|
| Age | NS | -- | −0.0067 | <0.0001 |
| Female | NS | -- | NS | -- |
| Smoking | NS | -- | NS | -- |
| BMI | 0.011 | 0.008 | 0.011 | 0.002 |
| Diabetes | −0.18 | 0.012 | NS | -- |
| Cirrhosis | −0.61 | <0.001 | −0.77 | <0.0001 |
| Sepsis/septic shock | NS | -- | −0.18 | 0.014 |
| Pneumonia/aspiration | NS | -- | NS | -- |
| APACHE III | −0.0063 | <0.0001 | NS | -- |
| ARDS | −0.23 | 0.0003 | −0.21 | 0.0001 |
| rs2854746a | 0.075 | 0.081 | 0.13 | 0.0006 |
| Adjusted R-square | 0.148 | 0.179 |
a
Genotype forced in to model for logIGF-1. Cells show parameter estimates (β) except as noted. IGF-1 is measured in ng/mL; IGFBP-3 is measured in ug/mL. NS = not significant (variables that did not survive the selection algorithm prior to model refit); BMI = body mass index; ARDS = acute respiratory distress syndrome; APACHE = Acute Physiology, Age and Chronic Health Evaluation.