Skip to main content
. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Ann N Y Acad Sci. 2015 Feb 27;1341:176–187. doi: 10.1111/nyas.12727

Figure 2.

Figure 2

Intronic sequences involved in LDI. (A) Diagrammatic representation of F14 and L14 binding sites within ISS-N1. Relative positioning of ISS-N1, GCRS, LS-1 and ISTL1 are shown. (B) Effect of F14 and L14 on SMN2 exon 7 splicing. Experiments were done using SMN2 minigenes.45 Sites of intronic deletions are shown by dotted lines (top panel). Bottom panel shows loss of inhibitory effect of L14 due to a 3-nt deletion that abrogates ISTL1.