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Rhabdomyosarcoma (RMS). Alveolar RMS grows between fibrous septa as nests of dyscohesive small round cells with high nuclear-cytoplasmic ratios (a). In the alveolar form of RMS, myogenin immunoexpression is diffuse (b). Embryonal RMS grows as round to spindle cells, often condensing beneath epithelial surfaces in a “cambium layer” (c). Myogenin is also positive in embryonal RMS, but the distribution is less diffuse than what is seen in the alveolar subtype (d)
