Table 2.
Characteristics | Cases (SERa+) | Controls (SERa−) | p |
---|---|---|---|
n = 130 | n = 130 | ||
Protocol of ovarian stimulation | 0.30 | ||
Protocol with GnRH agonists | 90 (69 %) | 81 (62 %) | |
Protocol with GnRH antagonists | 40 (31 %) | 49 (38 %) | |
Total amount of FSH used (IU) | 2908 ± 1316 | 2897 ± 1301 | 0.95 |
Duration of stimulation (days) | 10.1 ± 2.2 | 9.7 ± 2.0 | 0.10 |
Total number of follicles >10 mm | 10.6 ± 4.8 | 9.5 ± 5.8 | 0.12 |
Number of follicles >15 mm | 7.3 ± 3.5 | 6.4 ± 3.7 | 0.05 |
Estradiol at the end of stimulation (pg/ml) | 2404 ± 1296 | 1987 ± 1247 | 0.02 |
Oocyte retrieved | 9.0 [5.0–11.0] | 6.5 [3.0–10.0] | 0.011 |
1–5 | 37 (29 %) | 53 (41 %) | 0.09 |
6–9 | 37 (29 %) | 35 (27 %) | |
≥10 | 56 (43 %) | 42 (32 %) | |
Number of SERa metaphase II oocytes | 1 [1–2] | 0 [0–0] | 0.001 |
Number of oocytes discarded | 447/1157 (39 %) | 268/999 (27 %) | 0.001 |
SERa | 232/1157 (20 %) | 0/999 (0 %) | 0.001 |
Number of oocytes cryopreserved/retrieved | 106/1157 (9 %) | 131/999 (13 %) | 0.003 |
Number of inseminated oocytesa | 4.0 [2.0–7.0] | 4.0 [2.0–7.0] | 0.75 |
Fertilization rate (%)a | 75 [50–89] | 83 [60–100] | 0.05 |
Cancelled embryo transfera | 23 (18 %) | 10 (8 %) | 0.02 |
Absence of suitable oocytes | 10 (8 %) | 1 (1 %) | 0.24 |
Absence of fertilized oocytes | 6 (5 %) | 5 (4 %) | |
Absence of viable embryos | 7 (5 %) | 4 (3 %) | |
Delayed embryo transfer (freeze-all) | 14 (11 %) | 14 (11 %) | 1.00 |
Rate of good quality embryosa | |||
Day 2b | 32/76 (42 %) | 43/91 (47 %) | 0.55 |
Day 3 | 132/268 (49 %) | 134/295 (45 %) | 0.40 |
Day 5c | 42/133 (32 %) | 36/115 (31 %) | 1.00 |
Day of embryo transfera | 0.29 | ||
Day 2–3 | 78 (84 %) | 95 (90 %) | |
Day 5 | 15 (16 %) | 11 (10 %) | |
Number of embryos transferreda | 1.6 ± 0.6 | 1.7 ± 0.6 | 0.65 |
Data is reported as mean ± SD or number (%) or median [IQR] as appropriate
aIn the fresh cycle
bIncludes only patients undergoing day 2 embryo transfer
cIncludes only patients undergoing day 5 embryo transfer or day 5–6 freeze-all