Table 3.
Correlation of different CATSPER SNPs with asthenospermia
| CATSPER | Patient | Control | OR (95%CI) | OR§ (95%CI) | ||
|---|---|---|---|---|---|---|
| N | % | N | % | |||
| rs1893316 (C > T) | ||||||
| CC | 100 | 52.1 | 183 | 63.5 | 1.60 (1.11–2.32)* | 1.62 (1.02–2.60)* |
| CT/TT | 92 | 47.9 | 105 | 36.5 | ||
| rs1203998 (G > A) | ||||||
| GG | 50 | 26.0 | 92 | 31.9 | 1.33 (0.89–2.00) | 1.36 (0.77–2.40) |
| GA/AA | 142 | 74.0 | 196 | 68.1 | ||
| rs2845570 (G > T) | ||||||
| GG | 78 | 40.6 | 131 | 45.6 | 1.23 (0.85–1.78) | 1.50 (0.90–2.49) |
| GT/TT | 192 | 59.4 | 156 | 54.4 | ||
| rs3814747 (A > G) | ||||||
| AA | 159 | 82.8 | 235 | 81.6 | 0.92 (0.57–1.49) | 1.22 (0.69–2.19) |
| AG/GG | 33 | 17.2 | 53 | 18.4 | ||
| rs3814748 (A > G) | ||||||
| AA | 3 | 1.6 | 6 | 2.1 | 1.34 (0.33–5.43) | 0.96 (0.20–4.57) |
| AG/GG | 189 | 98.4 | 282 | 97.9 | ||
| rs3829937 (C > T) | ||||||
| CC | 156 | 81.2 | 219 | 76.0 | 0.73 (0.47–1.15) | 1.03 (0.58–1.81) |
| CT/TT | 36 | 18.8 | 69 | 24.0 | ||
| rs8042868 (C > T) | ||||||
| CC | 102 | 53.1 | 169 | 58.7 | 1.25 (0.87–1.81) | 1.27 (0.87–1.87) |
| CT/TT | 90 | 46.9 | 119 | 41.3 | ||
| rs17167765 (C > T) | ||||||
| CC | 156 | 81.2 | 240 | 83.3 | 1.15 (0.72–1.86) | 1.07 (0.64–1.79) |
| CT/TT | 36 | 18.8 | 48 | 16.7 | ||
| rs41284333 (A > G) | ||||||
| AA | 188 | 97.9 | 278 | 96.5 | 0.59 (0.18–1.91) | 0.47 (0.05–4.22) |
| AG/GG | 4 | 2.1 | 10 | 3.5 | ||
| rs11247866 (A > G) | ||||||
| AA | 186 | 96.9 | 274 | 95.5 | 0.68 (0.25–1.82) | 1.21 (0.19–7.62) |
| AG/GG | 6 | 3.1 | 13 | 4.5 | ||
| rs9970046 (A > G) | ||||||
| AA | 69 | 35.9 | 95 | 33.1 | 0.88 (0.60–1.30) | 0.95 (0.62–1.44) |
| AG/GG | 123 | 64.1 | 192 | 66.9 | ||
| rs17163674 (C > T) | ||||||
| CC | 164 | 85.4 | 237 | 82.3 | 0.79 (0.48–1.31) | 0.73 (0.43–1.26) |
| CT/TT | 28 | 14.6 | 51 | 17.7 | ||
§Logistic regression analysis, adjusted for confounders such as age, semen volume, and sperm concentration
*p < 0.05