Table 2.

Performance of DAS in the Discovery Set

Variable	P	AUC	95% CI
Total	< .001	0.657	0.586 to 0.727
Sex
Female	.0493	0.640	0.497 to 0.783
Male	< .001	0.663	0.581 to 0.744
Smoking status
Current smoker	< .001	0.672	0.585 to 0.758
Former smoker	.0158	0.637	0.516 to 0.759
Histology
Adenocarcinoma	.0349	0.618	0.509 to 0.728
SCC	.0013	0.708	0.590 to 0.826
Other NSCLC	.0131	0.662	0.521 to 0.802
Stage
I and II	.0144	0.735	0.568 to 0.903
III and IV	< .001	0.679	0.595 to 0.763
Timing of blood draw, months
0-6	< .001	0.710	0.613 to 0.808
> 6-12	.0257	0.610	0.510 to 0.710

Abbreviations: AUC, area under the curve; DAS, N¹,N¹²-diacetylspermine; NSCLC, non–small-cell lung cancer; SCC, squamous cell carcinoma.