Table 4.

Performance of the Combination of DAS and Pro-SFTPB in the Validation Set

Measure	Total	Timing of Blood Draw
		0-6 Months	> 6-12 Months
Pro-SFTPB + DAS
AUC	0.732	0.808	0.688
95% CI	0.673 to 0.791	0.724 to 0.891	0.609 to 0.767
Sensitivity at 95% specificity	0.222	0.350	0.176
Specificity at 95% sensitivity	0.181	0.388	0.140
P (v DAS)	< .001	< .001	< .001
P (v pro-SFTPB)	< .001	< .001	.0634
DAS
P	< .001	< .001	.0409
AUC	0.650	0.740	0.588
95% CI	0.585 to 0.716	0.634 to 0.846	0.505 to 0.671
Sensitivity at 95% specificity	0.120	0.275	0.059
Specificity at 95% sensitivity	0.111	0.063	0.088
Pro-SFTPB
P	< .001	< .001	< .001
AUC	0.699	0.741	0.675
95% CI	0.639 to 0.760	0.650 to 0.831	0.595 to 0.755
Sensitivity at 95% specificity	0.157	0.175	0.191
Specificity at 95% sensitivity	0.194	0.363	0.169

Abbreviations: AUC, area under the curve; DAS, N¹,N¹²-diacetylspermine; pro-SFTPB, pro-surfactant protein B.