Table A3.
Invasive IBE Rates for Clinically Relevant Subsets of Patients
| Variable | No. | 5 Years |
10 Years |
12 Years |
P | |||
|---|---|---|---|---|---|---|---|---|
| % | 95% CI | % | 95% CI | % | 95% CI | |||
| Age, years | ||||||||
| ≤ 49 | 106 | 2.9 | 0 to 6.2 | 5.1 | 0.7 to 9.5 | 6.4 | 1.4 to 11.4 | .57 |
| 50-69 | 312 | 3.4 | 1.3 to 5.4 | 6.8 | 3.8 to 9.7 | 8.1 | 4.8 to 11.4 | |
| ≥ 70 | 143 | 0.8 | 0 to 2.4 | 7.1 | 2.0 to 12.3 | 7.1 | 2.0 to 12.3 | |
| Minimum negative margin width, mm | ||||||||
| < 5 | 203 | 2.2 | 0.1 to 4.3 | 6.3 | 2.7 to 10.0 | 6.3 | 2.7 to 10.0 | .46 |
| 5-9 | 239 | 3.1 | 0.8 to 5.4 | 7.4 | 3.7 to 11.0 | 9.4 | 5.2 to 13.6 | |
| ≥ 10 | 119 | 2.7 | 0 to 5.8 | 4.7 | 0.7 to 8.8 | 6.0 | 1.3 to 10.7 | |
| Tumor size, mm* | ||||||||
| ≤ 5 | 226 | 2.3 | 0.3 to 4.3 | 4.8 | 1.9 to 7.8 | 4.8 | 1.9 to 7.8 | .17 |
| 6-10 | 231 | 1.9 | 0.1 to 3.7 | 7.9 | 4.0 to 11.7 | 10.0 | 5.5 to 14.5 | |
| > 10 | 104 | 5.4 | 0.8 to 10.0 | 6.8 | 1.5 to 12.0 | 8.5 | 2.3 to 14.8 | |
| CAP grade† | ||||||||
| Low | 61 | 1.8 | 0 to 5.3 | 5.5 | 0 to 11.6 | 5.5 | 0 to 11.6 | .69 |
| Intermediate | 249 | 2.2 | 0.3 to 4.1 | 5.3 | 2.2 to 8.3 | 6.6 | 3.1 to 10.2 | |
| High | 110 | 2.9 | 0 to 6.2 | 9.3 | 3.5 to 15.2 | 9.3 | 3.5 to 15.2 | |
NOTE. Analysis restricted to patients enrolled in cohort 1 (n = 561).
Abbreviations: CAP, College of American Pathologists; IBE, ipsilateral breast event.
*
Tumor size was based on central pathology review, when this information was available.
†
Restricted to the subset of cases for which a central pathology review was performed using current CAP guidelines.