Table A4.

IBE Rates and Subset of Invasive IBE Rates Comparing Current CAP Grading to Older Grading Classifications

Variable	No.	5 Years		10 Years		12 Years		P
		%	95% CI	%	95% CI	%	95% CI
IBE rates
Grade*
Low	63	5.1	0 to 10.8	12.5	3.8 to 21.3	12.5	3.8 to 21.3	.16
Intermediate	268	6.3	3.3 to 9.4	13.2	8.9 to 17.6	15.1	10.4 to 19.9
High	169	11.1	6.2 to 15.9	20.6	14.2 to 27.0	20.6	14.2 to 27.0
Grade†
Low	287	5.1	2.5 to 7.7	10.5	6.7 to 14.2	12.1	8.0 to 16.2	.02
Intermediate	239	7.6	4.1 to 11.1	17.7	12.5 to 22.9	19.1	13.6 to 24.5
High	64	17.9	8.3 to 27.5	23.9	12.9 to 35.0	23.9	12.9 to 35.0
Grade‡
Low	281	5.6	2.8 to 8.3	12.3	8.2 to 16.3	14.0	9.5 to 18.4	.01
Intermediate	280	6.5	3.5 to 9.5	12.7	8.5 to 16.9	14.9	10.2 to 19.5
High	104	15.0	8.0 to 22.0	24.6	15.7 to 33.4	24.6	15.7 to 33.4
Subset of invasive IBE rates
Grade*
Low	63	1.8	0 to 5.3	5.5	0 to 11.6	5.5	0 to 11.6	.19
Intermediate	268	2.0	0.3 to 3.8	5.4	2.4 to 8.4	6.7	3.2 to 10.1
High	169	4.5	1.2 to 7.7	11.7	6.4 to 17.0	11.7	6.4 to 17.0
Grade†
Low	287	1.8	0.2 to 3.4	5.3	2.5 to 8.1	5.8	2.8 to 8.8	.02
Intermediate	239	3.2	0.9 to 5.6	8.9	5.0 to 12.9	9.7	5.5 to 13.9
High	64	10.2	2.5 to 18.0	16.7	6.6 to 26.8	16.7	6.6 to 26.8
Grade‡
Low	281	1.5	0 to 3.0	5.4	2.5 to 8.3	5.9	2.9 to 9.0	.11
Intermediate	280	3.9	1.5 to 6.2	7.4	4.1 to 10.8	9.1	5.4 to 12.9
High	104	5.3	0.8 to 9.7	13.4	5.9 to 20.9	13.4	5.9 to 20.9

NOTE. Cases with unknown information were excluded from analysis.

Abbreviations: CAP, College of American Pathologists; IBE, ipsilateral breast event.

^*Second central pathology review using current CAP guidelines.

^†First central pathology review.²²

^‡Institutional pathology assessment at the time of study entry.