Figure 6.

Spike input disturbs cell firing in the presence of I_h. Single cell simulations illustrating the effect of action potential input, through an excitatory or an inhibitory synapse, on cell firing. (A) Without any form of input, the cell fired regularly in the presence of I_h. (B) In the absence of I_h, spike input through an excitatory synapse caused the cell to fire every time it received input. (D) In the presence of I_h, the same spike input disturbed the regular firing shown in (A), e.g., around 127 and 458 ms. (C) In the absence of I_h, spike input through an inhibitory synapse caused the cell to hyperpolarize every time it received input. (E) In the presence of I_h, the same spike input disturbed the regular firing shown in (A). Firing was prevented, e.g., around 118 and 227 ms, or delayed, e.g., around 790 ms.