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MIP-CCK mice are resistant to STZ-induced diabetes. A and B: glucose after STZ treatment and AUC above a glucose value of 150 mg/dl demonstrate that MIP-CCK mice are resistant to STZ-induced hyperglycemia (n = 7–9). C and D: wild-type and MIP-CCK pancreata harvested on day 8 were immunostained (DAPI, blue; insulin, red; TUNEL, green). E: quantitative analysis demonstrated reduced β-cell apoptosis in MIP-CCK mice (n = 5). *P < 0.05.
