TABLE 6.

Phenotypic DST, MTBDRplus, Xpert MTB-RIF, and VerePLEX Biosystem M. tuberculosis results for the 80 smear-positive MTBC culture-positive clinical specimens included in the study

Phenotypic DST resulta for:		MTBDRplus/sequencing resultb for the following gene:			Xpert MTB-RIF resultc for:		VerePLEX MTB resultb,d for the following gene:			No. of clinical specimense
RIF	INH	rpoB	katG	inhA	MTB	RIF	rpoB	katG	inhA
S	R	WT	WT	C-15T			WT	WT	C-15T	9
R	R	S531L	S315T1	WT			S531L	S315T1	WT	2
R	R	S531L	WT + S315T1	WT			S531L	WT + S315T1	WT	1
S	R	WT	WT	WT			WT	WT	WT	6
R	R	D516V	S315T1	WT			D516V	S315T1	WT	2
R	R	S531L	WT	WT			S531L	WT	WT	2
S	R	WT	S315T1	WT			WT	S315T1	WT	4
R	R	S531L	S315T1/T2	WT			S531L	S315T1/T2	WT	1
R	R	Q513P	S315T1	WT			Δ 510–513 WT	S315T1	WT	1
S	R	WT	S315N	WT			WT	Δ 313–317 WT	WT	1
R	S	S531L	WT	WT			S531L	WT	WT	1
R	R	S531L	WT	C-15T			S531L	Δ 313–317 WT	WT	1
S	S	WT	WT	WT			WT	WT	WT	15
R	R	Δ 518–525 WT, Δ 530–533 WT	S315T1	WT			Δ 523–526 WT, S531L	S315T1	WT	1
		D516V	S315T1	T-8C			D516V	S315T1	T-8C	1
		WT	WT	WT			WT	WT	WT	15
		WT	S315T1	WT			WT	S315T1	WT	1
S	S						WT	WT	WT	9
					pos	WT	WT	WT	WT	4
		WT	WT	WT			PCNV	PCNV	PCNV	1
S	S	ND	S315T1	WT			MTBND	MTBND	MTBND	1
S	S	ND	WT	WT			ND	ND	ND	1

^aThe phenotypic drug susceptibility testing results for rifampin and isoniazid are given as follows: R, resistant; S, sensitive.

^bThe results for the 80 smear-positive, MTBC culture-positive isolates found by the MTBDRplus assay and sequencing or by the VerePLEX Biosystem are shown (wild type [WT] or mutant). Δ, no WT signal; ND, not detected.

^cMTB, M. tuberculosis; pos, positive.

^dPCNV, PCR controls not valid; MTBND, M. tuberculosis not detected; ND, not detected.

^eThe number of smear-positive, MTBC culture-positive clinical specimens applies to all the tests.