TABLE 1.
Plasma metabolites with higher levels in TB patients than those in CAP patients and controls without active infection
| Compound | Experimental mass (m/z) | Retention time (min) | Ion | MS/MS fragment masses (m/z) | VIP scorea | Elemental composition | Putative identity |
|---|---|---|---|---|---|---|---|
| 1 | 538.5190 | 33.02 | M+H | 252.2672, 264.2682, 282.2794, 502.4987, 520.5095, 538.5193 | 1.37 | C34H67NO3 | Ceramide (d18:1/16:0) |
| 2 | 429.3738 | 32.22 | M+H | 149.0976, 165.0924, 177.0935, 191.1083, 205.1228, 219.1382, 303.2339, 401.3434, 411.3598, 429.3733 | 4.54 | C29H48O2 | 4α-Formyl-4β-methyl-5α-cholesta-8-en-3β-ol |
| 3 | 319.2276 | 12.73 | M-H | 135.1145, 179.1069, 257.2274, 301.2181, 319.2274 | 1.02 | C20H32O3 | 12(R)-HETE |
| 4 | 465.3039 | 33 | M-H | 79.9580, 96.9594, 465.3059 | 1.29 | C27H46O4S | Cholesterol sulfate |
a
VIP, variable importance in projection score in PLS-DA analyses. A VIP score of >1 is considered to be statistically significant.